IDO/kynurenine pathway in cancer: possible therapeutic approaches

EE Abd El-Fattah - Journal of Translational Medicine, 2022 - Springer
Cancer is one of the leading causes of death in both men and women worldwide. One of the
main changes associated with cancer progression, metastasis, recurrence, and …

Impact of benzo [a] pyrene with other pollutants induce the molecular alternation in the biological system: Existence, detection, and remediation methods

K Saravanakumar, S Sivasantosh… - Environmental …, 2022 - Elsevier
The exposure of benzo [a] pyrene (BaP) in recent times is rather unavoidable than ever
before. BaP emissions are sourced majorly from anthropogenic rather than natural …

Benzo [a] pyrene immunogenetics and immune archetype reprogramming of lung

EE Abd El-Fattah, AM Abdelhamid - Toxicology, 2021 - Elsevier
Overexposure to carcinogenic precursor, benzo [a] pyrene [BaP], modulates the lung
immune microenvironment. The present review seeks to elucidate novel pathways behind …

Targeting CD166+ lung cancer stem cells: Molecular study using murine dendritic cell vaccine

NE El-Ashmawy, ML Salem, EE Abd El-Fattah… - Toxicology and applied …, 2021 - Elsevier
Purpose Cancer stem cells (CSC) are the most common causes of lung cancer relapse and
mouse resistance to chemotherapy. CD166 was identified as CSC marker for lung cancer …

[HTML][HTML] Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application

AM Abdelhamid, S Saber, ME Youssef… - Biomedicine & …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is on the rise worldwide, and its incidence in diabetic
patients is two to three times that of non-diabetics. Current therapeutic options fail to provide …

Metformin modulate immune fitness in hepatocellular carcinoma: Molecular and cellular approach

EE Abd El-Fattah, AY Zakaria - International Immunopharmacology, 2022 - Elsevier
Hyperinsulinemia, hyperglycemia, and chronic inflammation may play a role in
hepatocellular carcinoma (HCC). Treatment of HCC patients with the antidiabetic medication …

Dynamic changes of DNA methylation induced by benzo (a) pyrene in cancer

H Wang, B Liu, H Chen, P Xu, H Xue, J Yuan - Genes and Environment, 2023 - Springer
Abstract Benzo (a) pyrene (BaP), the earliest and most significant carcinogen among
polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and …

Benzo [a] pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer

KR Washimkar, MS Tomar, S Ishteyaque… - Chemico-Biological …, 2023 - Elsevier
Lung cancer is an aggressive malignancy and the leading cause of cancer-related deaths.
Benzo [a] pyrene (B [a] P), a polycyclic hydrocarbon, plays a pivotal role in lung …

Reprograming immune microenvironment modulates CD47 cancer stem cells in hepatocellular carcinoma

EE Abd El-Fattah, HM Selim - International Immunopharmacology, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. There are different
therapeutic approaches to cancer eradication such as chemotherapy, radiotherapy, and …

Targeting HSP47 and HSP70: promising therapeutic approaches in liver fibrosis management

EE Abd El-Fattah, AY Zakaria - Journal of Translational Medicine, 2022 - Springer
Liver fibrosis is a liver disease in which there is an excessive buildup of extracellular matrix
proteins, including collagen. By regulating cytokine production and the inflammatory …