ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease

DSA Simpson, PL Oliver - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Biochemistry of peroxynitrite and protein tyrosine nitration

G Ferrer-Sueta, N Campolo, M Trujillo… - Chemical …, 2018 - ACS Publications
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

NOX dependent ROS generation and cell metabolism

T Pecchillo Cimmino, R Ammendola… - International Journal of …, 2023 - mdpi.com
Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic
natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS …

Light‐activated decellularized extracellular matrix‐based bioinks for volumetric tissue analogs at the centimeter scale

H Kim, B Kang, X Cui, SH Lee, K Lee… - Advanced Functional …, 2021 - Wiley Online Library
Tissue engineering requires not only tissue‐specific functionality but also a realistic scale.
Decellularized extracellular matrix (dECM) is presently applied to the extrusion‐based 3D …

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

A Panday, MK Sahoo, D Osorio, S Batra - Cellular & molecular …, 2015 - nature.com
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

[HTML][HTML] The role of NADPH oxidases in infectious and inflammatory diseases

JP Taylor, MT Hubert - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …

A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals

A Parthasarathy, PJ Cross, RCJ Dobson… - Frontiers in molecular …, 2018 - frontiersin.org
Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Reactive oxygen species: from health to disease

K Brieger, S Schiavone, FJ Miller Jr, KH Krause - Swiss medical weekly, 2012 - smw.ch
Upon reaction with electrons, oxygen is transformed into reactive oxygen species (ROS). It
has long been known that ROS can destroy bacteria and destroy human cells, but research …