Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Protein quality control (proteostasis) depends on constant protein degradation and
resynthesis, and is essential for proper homeostasis in systems from single cells to whole …

Erythropoietin (Epo) has been thought to act exclusively on erythroid progenitor cells. The
identification of Epo receptor (EpoR) in non-haematopoietic cells and tissues including …

Exposure to hypobaric hypoxia at high altitude (above 2500 m asl) causes cognitive
impairment, mostly attributed to changes in brain perfusion and consequently neuronal …

Pyruvate dehydrogenase kinase (PDK), which phosphorylates the pyruvate dehydrogenase
complex, regulates glucose metabolism in skeletal muscle. PDK1, an isozyme whose …

Altitude training has been widely adopted. This study aimed to establish a mice model to
determine the time point for achieving the best endurance at the lowland. C57BL/6 and …

Janus, a double-faced Roman god, was the god of beginnings and ends, and has given his
name to the first month of the year. The state of “hypoxia” as a trigger for EPO seems “to fool …

Intermittent hypobaric hypoxia (IHH) exposure, accompanied or not with active recovery, can
help to skeletal muscle repair. However, the erythropoietic response elicited can disturb …

Intermittent hypobaric hypoxia (IHH) has been the focus of important research in
cardioprotection, and it has been associated with several mechanisms. Intermittent …

Aim The aim of this study is to investigate the effect of pre-endurance training on the
prevention of alcohol-induced acute hepatic injury and on hepatic mitophagy. Methods Forty …