Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity
Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7)
have been implicated in key biological and pathophysiological processes, including …
have been implicated in key biological and pathophysiological processes, including …
[HTML][HTML] Design and development of autotaxin inhibitors
Y Jia, Y Li, XD Xu, Y Tian, H Shang - Pharmaceuticals, 2021 - mdpi.com
Autotaxin (ATX) is the only enzyme of the ecto-nucleotide pyrophosphatase/
phosphodiesterase (ENPP2) family with lysophospholipase D (lysoPLD) activity, which is …
phosphodiesterase (ENPP2) family with lysophospholipase D (lysoPLD) activity, which is …
Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
M Centonze, G Di Conza, M Lahn, I Fabregat… - Journal of Experimental …, 2023 - Springer
Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to
lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes …
lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes …
Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Stroke penumbra injury caused by excess glutamate is an important factor in determining
stroke outcome; however, several therapeutic approaches aiming to rescue the penumbra …
stroke outcome; however, several therapeutic approaches aiming to rescue the penumbra …
Autotaxin facilitates selective LPA receptor signaling
Summary Autotaxin (ATX; ENPP2) produces the lipid mediator lysophosphatidic acid (LPA)
that signals through disparate EDG (LPA 1–3) and P2Y (LPA 4–6) G protein-coupled …
that signals through disparate EDG (LPA 1–3) and P2Y (LPA 4–6) G protein-coupled …
[HTML][HTML] Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
E Matas-Rico, E Frijlink, I van der Haar Àvila… - Cell reports, 2021 - cell.com
Summary Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates
multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA …
multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA …
AGE/non-AGE glycation: An important event in rheumatoid arthritis pathophysiology
Monu, P Agnihotri, S Biswas - Inflammation, 2022 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease that gradually
affects the synovial membrane and joints. Many intrinsic and/or extrinsic factors are crucial in …
affects the synovial membrane and joints. Many intrinsic and/or extrinsic factors are crucial in …
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis
R Booijink, F Salgado‐Polo, C Jamieson… - EMBO molecular …, 2022 - embopress.org
The lysophosphatidic acid (LPA) signaling axis is an important but rather underexplored
pathway in liver disease. LPA is predominantly produced by Autotaxin (ATX) that has gained …
pathway in liver disease. LPA is predominantly produced by Autotaxin (ATX) that has gained …
Coupled electrostatic and hydrophobic destabilisation of the gelsolin-actin complex enables facile detection of ovarian cancer biomarker lysophosphatidic acid
K Davoudian, S Bhattacharya, D Thompson… - Biomolecules, 2023 - mdpi.com
Lysophosphatidic acid (LPA) is a promising biomarker candidate to screen for ovarian
cancer (OC) and potentially stratify and treat patients according to disease stage. LPA is …
cancer (OC) and potentially stratify and treat patients according to disease stage. LPA is …
Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators
JM Clark, F Salgado-Polo, SJF Macdonald… - Journal of Medicinal …, 2022 - ACS Publications
Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid
(LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in …
(LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in …