Sarcopenia, osteoporosis and frailty

E Gielen, J Dupont, M Dejaeger, MR Laurent - Metabolism, 2023 - Elsevier
Muscles and bones are intricately connected tissues displaying marked co-variation during
development, growth, aging, and in many diseases. While the diagnosis and treatment of …

Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss

CJ Rosen, MC Horowitz - Nature Reviews Endocrinology, 2023 - nature.com
Adipose tissue is a dynamic component of the bone marrow, regulating skeletal remodelling
and secreting paracrine and endocrine factors that can affect haematopoiesis, as well as …

Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow

X Liu, Y Gu, S Kumar, S Amin, Q Guo, J Wang, CL Fang… - Cell metabolism, 2023 - cell.com
The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …

Testosterone restores body composition, bone mass, and bone strength following early puberty suppression in a mouse model mimicking the clinical strategy in trans …

V Dubois, S Ciancia, S Doms… - Journal of Bone and …, 2023 - academic.oup.com
Transgender youth increasingly present at pediatric gender services. Some of them receive
long‐term puberty suppression with gonadotropin‐releasing hormone analogues (GnRHa) …

Prostate cancer and bone: clinical presentation and molecular mechanisms

KV Wells, ML Krackeler, MK Jathal… - Endocrine-related …, 2023 - erc.bioscientifica.com
Prostate cancer (PCa) is an increasingly prevalent health problem in the developed world.
Effective treatment options exist for localized PCa, but metastatic PCa has fewer treatment …

The impact of interventional weight loss on bone marrow adipose tissue in people living with obesity and its connection to bone metabolism

M Tencerova, G Duque, KM Beekman, A Corsi… - Nutrients, 2023 - mdpi.com
This review focuses on providing physicians with insights into the complex relationship
between bone marrow adipose tissue (BMAT) and bone health, in the context of weight loss …

Bone marrow adipose tissue: regulation of osteoblastic niche, hematopoiesis and hematological malignancies

R Labella, M Vujačić, D Trivanović - Stem Cell Reviews and Reports, 2023 - Springer
Bone marrow adipose tissue (BMAT) creates a specific microniche within multifunctional
bone marrow (BM) ecosystem which imposes changes in surrounding cells and at systemic …

[HTML][HTML] New insights into calorie restriction induced bone loss

L Liu, CJ Rosen - Endocrinology and Metabolism, 2023 - synapse.koreamed.org
Caloric restriction (CR) is now a popular lifestyle choice due to its ability in experimental
animals to improve lifespan, reduce body weight, and lessen oxidative stress. However …

Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates an in vitro model of bone marrow adipocyte subtypes

J Tratwal, G Falgayrac, A During… - Frontiers in …, 2022 - frontiersin.org
Bone marrow adipocytes (BMAds) constitute the most abundant stromal component of adult
human bone marrow. Two subtypes of BMAds have been described, the more labile …

Update on the role of glucocorticoid signaling in osteoblasts and bone marrow adipocytes during aging

H Bensreti, DW Alhamad, AM Gonzalez… - Current osteoporosis …, 2023 - Springer
Abstract Purpose of Review Bone marrow adipose tissue (BMAT) in the skeleton likely plays
a variety of physiological and pathophysiological roles that are not yet fully understood. In …