Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip
spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus …

Candida infections have increased due to the growth and expansion of susceptible patient
populations. The azole fluconazole is the most widely prescribed antifungal, but rising rates …

The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis,
causing infections ranging from superficial to life-threatening disseminated disease. The …

The ATP binding cassette (ABC) transporters, first discovered as high-affinity nutrient
importers in bacteria, rose to prominence when their ability to confer multidrug resistance …

ATP-binding cassette (ABC) superfamily members have a key role as nutrient importers and
exporters in bacteria. However, their role as drug exporters in eukaryotes brought this …

Pathogenic fungi, including Candida glabrata, develop strategies to grow and survive both
in vitro and in vivo under azole stress. However, the mechanisms by which yeast cells …

Among existing fungal pathogens, Candida glabrata is outstanding in its capacity to rapidly
develop resistance to currently used antifungal agents. Resistance to the class of azoles …

Lipids are valuable compounds present in all living organisms, which display an array of
functions related to compartmentalization, energy storage and enzyme activation …

The increased numbers of patients with compromised immune systems in the last three
decades have increased the chances of life-threatening fungal infections. Numerous …

Sterols are essential for eukaryotic cells and are crucial in cellular membranes' structure,
function, fluidity, permeability, adaptability to environmental stressors, and host-pathogen …