Microbial indicators as a diagnostic tool for assessing water quality and climate stress in coral reef ecosystems
Microorganisms play a fundamental role in the functioning and stability of coral reef
ecosystems. However, environmental disturbances can trigger alterations to the natural …
ecosystems. However, environmental disturbances can trigger alterations to the natural …
Synonymous codons direct cotranslational folding toward different protein conformations
F Buhr, S Jha, M Thommen, J Mittelstaet, F Kutz… - Molecular cell, 2016 - cell.com
In all genomes, most amino acids are encoded by more than one codon. Synonymous
codons can modulate protein production and folding, but the mechanism connecting codon …
codons can modulate protein production and folding, but the mechanism connecting codon …
Gene circuit performance characterization and resource usage in a cell-free “breadboard”
The many successes of synthetic biology have come in a manner largely different from those
in other engineering disciplines; in particular, without well-characterized and simplified …
in other engineering disciplines; in particular, without well-characterized and simplified …
Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases
K Gemperlein, D Dietrich, M Kohlstedt, G Zipf… - Nature …, 2019 - nature.com
Long-chain polyunsaturated fatty acids (LC-PUFAs), particularly the omega-3 LC-PUFAs
eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid …
eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid …
Bacterial growth physiology and RNA metabolism
AG Planson, V Sauveplane, E Dervyn… - Biochimica et Biophysica …, 2020 - Elsevier
Bacteria are sophisticated systems with high capacity and flexibility to adapt to various
environmental conditions. Each prokaryote however possesses a defined metabolic …
environmental conditions. Each prokaryote however possesses a defined metabolic …
Time-resolved dual RNA-seq reveals extensive rewiring of lung epithelial and pneumococcal transcriptomes during early infection
R Aprianto, J Slager, S Holsappel, JW Veening - Genome biology, 2016 - Springer
Background Streptococcus pneumoniae, the pneumococcus, is the main etiological agent of
pneumonia. Pneumococcal infection is initiated by bacterial adherence to lung epithelial …
pneumonia. Pneumococcal infection is initiated by bacterial adherence to lung epithelial …
Trade-offs between tRNA abundance and mRNA secondary structure support smoothing of translation elongation rate
TE Gorochowski, Z Ignatova… - Nucleic acids …, 2015 - academic.oup.com
Translation of protein from mRNA is a complex multi-step process that occurs at a non-
uniform rate. Variability in ribosome speed along an mRNA enables refinement of the …
uniform rate. Variability in ribosome speed along an mRNA enables refinement of the …
Accessibility of the Shine-Dalgarno sequence dictates N-terminal codon bias in E. coli
Despite considerable efforts, no physical mechanism has been shown to explain N-terminal
codon bias in prokaryotic genomes. Using a systematic study of synonymous substitutions in …
codon bias in prokaryotic genomes. Using a systematic study of synonymous substitutions in …
The impact of leadered and leaderless gene structures on translation efficiency, transcript stability, and predicted transcription rates in Mycobacterium smegmatis
Regulation of gene expression is critical for Mycobacterium tuberculosis to tolerate stressors
encountered during infection and for nonpathogenic mycobacteria such as Mycobacterium …
encountered during infection and for nonpathogenic mycobacteria such as Mycobacterium …
Quantifying the effect of ribosomal density on mRNA stability
Gene expression is a fundamental cellular process by which proteins are eventually
synthesized based on the information coded in the genes. This process includes four major …
synthesized based on the information coded in the genes. This process includes four major …