Paleoproteomics, the study of ancient proteins, is a rapidly growing field at the intersection of
molecular biology, paleontology, archaeology, paleoecology, and history. Paleoproteomics …

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …

Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Mitochondrial network remodeling between fused and fragmented states facilitates
mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated …

Ageing is driven by a loss of cellular integrity. Given the major role of ubiquitin modifications
in cell function, here we assess the link between ubiquitination and ageing by quantifying …

Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …