Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …

The key regulators of the transcriptional response to hypoxia and inflammation (hypoxia
inducible factor, HIF, and nuclear factor-kappa B, NF-κB, respectively) are evolutionarily …

We report genome-wide ancient DNA from 49 individuals forming four parallel time transects
in Belize, Brazil, the Central Andes, and the Southern Cone, each dating to at least∼ 9,000 …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …

Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …

Humans and their domestic animals have lived and thrived in high-altitude environments
worldwide for thousands of years. These populations have developed a number of …