Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous
physiological processes, including metabolism, post-translational protein modification, and …

Aging is accompanied by a decline in the healthy function of multiple organ systems, leading
to increased incidence and mortality from diseases such as type II diabetes mellitus …

Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …

Nicotinamide adenine dinucleotide (NAD+) is both a coenzyme for hydride-transfer enzymes
and a substrate for NAD+-consuming enzymes, which include ADP-ribose transferases, poly …

NAD+ is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a
source of ADPribosyl groups used in various reactions, including those that retard aging in …

Recent studies have revealed new roles for NAD and its derivatives in transcriptional
regulation. The evolutionarily conserved Sir2 protein family requires NAD for its deacetylase …

A major cause of cell death caused by genotoxic stress is thought to be due to the depletion
of NAD+ from the nucleus and the cytoplasm. Here we show that NAD+ levels in …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …