The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …

Atomic force microscopy is an increasingly attractive tool to study how peptides disrupt
membranes. Often performed on reconstituted lipid bilayers, it provides access to time and …

Polymyxins are last-resort antibiotics with potent activity against multi-drug resistant
pathogens. They interact with lipopolysaccharide (LPS) in bacterial membranes, but …

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing
problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) …

There is a need to discover and develop non-toxic antibiotics that are effective against
metabolically dormant bacteria, which underlie chronic infections and promote antibiotic …

Bacteriophage lysins, also known as endolysins or murein hydrolases, are hydrolytic
enzymes produced by bacteriophages during the final stage of the lytic cycle to enable …

Activity tests for synthetic antimicrobial compounds are often limited to the minimal inhibitory
concentration assay using standard media and bacterial strains. In this study, a family of …

Pseudomonas aeruginosa (PA) is an opportunistic pathogen, which causes serious lung
infections in immunocompromised patients. Traditional oral intake of large quantities of …

Gram-negative bacteria are becoming resistant to almost all currently available antibiotics.
Systemically designed antimicrobial peptides (AMPs) are attractive agents to enhance the …

Biological control mechanisms of plant diseases have been intensively studied. However,
how plant pathogens respond to and resist or alleviate biocontrol agents remains largely …