Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy

A Bulashevska, Z Nacsa, F Lang, M Braun… - Frontiers in …, 2024 - frontiersin.org
Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular
focus on neoantigens as promising targets for personalized treatments. The convergence of …

[HTML][HTML] Transformers meets neoantigen detection: a systematic literature review

V Machaca, V Goyzueta, MG Cruz, E Sejje… - Journal of Integrative …, 2024 - degruyter.com
Cancer immunology offers a new alternative to traditional cancer treatments, such as
radiotherapy and chemotherapy. One notable alternative is the development of personalized …

[HTML][HTML] Improved prediction of MHC-peptide binding using protein language models

N Hashemi, B Hao, M Ignatov, IC Paschalidis… - Frontiers in …, 2023 - frontiersin.org
Major histocompatibility complex Class I (MHC-I) molecules bind to peptides derived from
intracellular antigens and present them on the surface of cells, allowing the immune system …

[HTML][HTML] Transfer learning improves pMHC kinetic stability and immunogenicity predictions

R Fasoulis, MM Rigo, DA Antunes, G Paliouras… - ImmunoInformatics, 2024 - Elsevier
The cellular immune response comprises several processes, with the most notable ones
being the binding of the peptide to the Major Histocompability Complex (MHC), the peptide …

Neoantigen Detection Using Transformers and Transfer Learning in the Cancer Immunology Context

VEM Arceda - International Conference on Practical Applications of …, 2023 - Springer
Neoantigen detection is the most critical step in developing personalized vaccines in cancer
immunology. However, neoantigen detection depends on the correct pMHC binding and …

Deep Learning and Transformers in MHC-Peptide Binding and Presentation Towards Personalized Vaccines in Cancer Immunology: A Brief Review

VE Machaca, V Goyzueta, M Cruz, Y Tupac - International Conference on …, 2023 - Springer
Cancer immunology is a new alternative to traditional cancer treatments like radiotherapy
and chemotherapy. There are some strategies, but neoantigen detection for developing …

Enhancing Protein Interaction Prediction Using Deep Learning and Protein Language Models

N Hashemi - 2023 - search.proquest.com
Proteins are large macromolecules that play critical roles in many cellular activities in living
organisms. These include catalyzing metabolic reactions, mediating signal transduction …

Check for Neoantigen Detection Using Transformers and Transfer Learning in the Cancer Immunology Context Vicente Enrique Machaca Arceda ()

NDU Transformers - Practical Applications of Computational …, 2023 - books.google.com
Neoantigen detection is the most critical step in developing personalized vaccines in cancer
immunology. However, neoantigen detection depends on the correct pMHC binding and …

[PDF][PDF] Explainable Artificial Intelligence for Peptide Presentation Using Statistical Fault Localisation Techniques

G Rooijackers - project-archive.inf.ed.ac.uk
The rise of complex black-box machine learning models has led to an increase in
explainable AI research to understand their reasoning and build trust in these models. Trust …