Multicomponent reactions (MCRs) are generally defined as reactions where more than two
staring materials react to form a product, incorporating essentially all of the atoms of the …

The Ugi-4CR is by far one of the most successful multicomponent reactions leading to high
structural diversity and molecular complexity. However, the reaction mostly affords a linear …

We report a convenient protocol for a nitrogen atom insertion into indenes to afford
isoquinolines. The reaction uses a combination of commercially available phenyliodine (III) …

Robotic platforms for chemistry are developing rapidly but most systems are not currently
able to adapt to changing circumstances in real-time. We present a dynamically …

A four-component coupling process involving sequential reactions of aldehydes, primary
amines, acid chlorides, and nucleophiles has been developed to prepare multifunctional …

The amalgamation of two of combinatorial chemistry's most attractive concepts—natural
product libraries and multicomponent reactions (MCRs)—should provide a powerful tactic …

A two-step sequence involving an Ugi four-component reaction (Ugi-4CR) and a palladium-
catalyzed intramolecular amidation of aryl iodide has been developed for rapid access to …

Synthesis of Highly Substituted Isoquinolone Derivatives by Nickel-Catalyzed Annulation of
2-Halobenzamides with Alkynes | Organic Letters ACS ACS Publications C&EN CAS Find my …

A novel ligand-free palladium-catalyzed cascade reaction for the synthesis of highly diverse
isoquinolin-1 (2 H)-one derivatives from isocyanide and amide precursors synthesized by …

Linear amides 4, prepared in one step by the Ugi four-component reaction, were converted
to 3, 4-dihydroquinoxalin-3-ones (5) or to 2-(2-oxoindolin-1-yl) acetamides (6) dependent on …