Systemic lupus erythematosus (SLE) is a severe chronic systemic autoimmune disease
caused by complicated interactions among genetic, epigenetic, and immunological factors …

Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant
disease, characterized by multiple organ damage, that in its most severe forms can be life …

BACKGROUND. Plasmacytoid DCs (pDC) produce large amounts of type I IFN (IFN-I),
cytokines convincingly linked to systemic lupus erythematosus (SLE) pathogenesis. BIIB059 …

Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the
periphery is critical for the initiation of CD8+ T cell responses. Several DC subsets are …

In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged as an
important player in the regulation of T cell responses and a promising target in vaccination …

Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …

Human skin immune homeostasis, and its regulation by specialized subsets of tissue-
residing immune sentinels, is poorly understood. In this study, we identify an …

Detection of cytosolic DNA by the cyclic GMP-AMP (cGAMP) synthase (cGAS)–stimulator of
interferon genes (STING) pathway provides immune defense against pathogens and cancer …

Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus
erythematosus. The general consensus is that 60% of lupus patients will develop clinically …

Objective Systemic lupus erythematosus (SLE), the most common form of lupus, is a
multisystemic rheumatic disease with different clinical features that generally affect women …