Given the high prevalence of early life stress (ELS) and the potential physiological
dysregulation such experiences can lead to, this meta-analysis tested the relationship …

Childhood adversity is associated with physiologic dysregulation across multiple biological
systems; however, relatively little is known about whether these changes are reversible with …

Early-life adversity has been associated with a life-long increased risk for psychopathology
and chronic health problems. These long-term negative effects have been explained …

Nonhuman animal models reveal that the hypothalamic–pituitary–adrenocortical (HPA) axis
calibrates to the harshness of the environment during a sensitive period in infancy. Humans …

Stress and Health: Biological and Psychological Interactions, by William R. Lovallo, is a brief
and accessible examination of psychological stress and its psychophysiological …

Stressful experiences affect biological stress systems, such as the hypothalamic–pituitary–
adrenal (HPA) axis. Life stress can potentially alter regulation of the HPA axis and has been …

Early life stress (ELS) may increase the risk of anxiety throughout the life course. Whether
this effect extends to late adulthood is poorly known. In our study comprising 1872 …

Objective High cardiovascular reactions to psychological stress are associated with the
development of hypertension, systemic atherosclerosis, and cardiovascular disease …

Early life stress (ELS) is a widely studied concept due to both its prevalent nature and its
(presumed) detrimental consequences. In this review, we discuss the relationship between …

Many promising findings support the notion that social relationships can dampen
hypothalamic-pituitary-adrenocortical (HPA) axis stress responses and protect individuals …