The biophysical properties of existing optogenetic tools constrain the scale, speed, and
fidelity of precise optogenetic control. Here, we use structure-guided mutagenesis to …

Plethora of research has shed light on the critical role of synaptic dysfunction in various
neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's …

Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative
focused on development of technologies for advancement of neuroscience. For the last …

Two-photon voltage imaging has long been heralded as a transformative approach capable
of answering many long-standing questions in modern neuroscience. However, exploiting …

Subject of study. An overview of modern neural-network-based methods for digital and
computer-generated holography is presented. Relevant works on phase and amplitude …

The development of efficient genetically encoded indicators and actuators has opened up
the possibility of reading and manipulating neuronal activity in living tissues with light. To …

Understanding the intricate synaptic connectivity in living neural circuits is crucial for
unraveling the relationship between network structure and function, as well as its evolution …

Two-photon light-targeting optogenetics allows controlling selected subsets of neurons with
near single-cell resolution and high temporal precision. To push forward this approach, we …

The design of biomaterials that can reconfigure on-demand in response to external stimuli is
an emerging area in materials research. However, achieving reversible assembly of protein …

One of the most audacious goals of modern neuroscience is unraveling the complex web of
causal relations underlying the activity of neuronal populations on a whole-brain scale. This …