Neurodegenerative diseases represent a large group of neurological disorders including
Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's …

Animal models are essential for investigating the pathogenesis and developing the
treatment of human diseases. Identification of genetic mutations responsible for …

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG
trinucleotide repeat expansion in the huntingtin gene. Previously, we showed strong …

Objective Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused
by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a …

Therapies targeting mutant huntingtin DNA, mRNA, and protein have a chance at becoming
the first disease-modifying treatments for Huntington's disease, a fatal inherited …

Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic
stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these …

An important component for successful translation of cell replacement‐based therapies into
clinical practice is the utilization of large animal models to conduct efficacy and/or safety cell …

Long-term treatment with 3-nitropropionic acid (3-NPA), a toxin derived from plants and
fungi, may reproduce symptoms and biochemical characteristics of Huntington's disease …

Genetically modified rodent models of Huntington's disease (HD) have been especially
valuable to our understanding of HD pathology and the mechanisms by which the mutant …

The use of minipigs as an alternative nonclinical species has increased in the last 20 years.
The Society of Toxicologic Pathology (STP) has produced generic “best practice” …