Ergosterol is an essential component of fungal cell membranes that determines the fluidity,
permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a …

For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …

Budding yeast Saccharomyces cerevisiae survives in microenvironments utilizing networks
of regulators and ATP‐binding cassette (ABC) transporters to circumvent toxins and a variety …

Iron participates as an essential cofactor in the biosynthesis of critical cellular components,
including DNA, proteins and lipids. The ergosterol biosynthetic pathway, which is an …

DNA variants that alter gene expression contribute to variation in many phenotypic traits. In
particular, trans-acting variants, which are often located on different chromosomes from the …

A high-confidence map of the direct, functional targets of each transcription factor (TF)
requires convergent evidence from independent sources. Two significant sources of …

Saccharomyces cerevisiae is a eukaryotic organism with a clear genetic background and
mature gene operating system; in addition, it exhibits environmental tolerance. Therefore, S …

In Saccharomyces cerevisiae, the transcriptional repressor Opi1 regulates the expression of
genes involved in phospholipid synthesis responding to the abundance of the phospholipid …

Motivation The activity of a transcription factor (TF) in a sample of cells is the extent to which
it is exerting its regulatory potential. Many methods of inferring TF activity from gene …

Defining the in vivo DNA binding specificity of transcription factors (TFs) has relied nearly
exclusively on chromatin immunoprecipitation (ChIP). While ChIP reveals TF binding …