Freezing revisited: coordinated autonomic and central optimization of threat coping
Animals have sophisticated mechanisms for coping with danger. Freezing is a unique state
that, upon threat detection, allows evidence to be gathered, response possibilities to be …
that, upon threat detection, allows evidence to be gathered, response possibilities to be …
Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine
R Cools, AFT Arnsten - Neuropsychopharmacology, 2022 - nature.com
The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …
yet is tremendously dependent on a precise neurochemical environment for proper …
Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors
The serotonin system modulates a wide variety of emotional behaviors and states, including
reward processing, anxiety, and social interaction. To reveal the underlying patterns of …
reward processing, anxiety, and social interaction. To reveal the underlying patterns of …
The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery
Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …
clarifying their nature, identifying their biological underpinnings, and determining their …
Semantic space theory: A computational approach to emotion
Within affective science, the central line of inquiry, animated by basic emotion theory and
constructivist accounts, has been the search for one-to-one mappings between six emotions …
constructivist accounts, has been the search for one-to-one mappings between six emotions …
Mapping the passions: Toward a high-dimensional taxonomy of emotional experience and expression
What would a comprehensive atlas of human emotions include? For 50 years, scientists
have sought to map emotion-related experience, expression, physiology, and recognition in …
have sought to map emotion-related experience, expression, physiology, and recognition in …
[HTML][HTML] Directed evolution of a selective and sensitive serotonin sensor via machine learning
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for
psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will …
psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will …
[HTML][HTML] Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors
Sex differences in pain severity, response, and pathological susceptibility are widely
reported, but the neural mechanisms that contribute to these outcomes remain poorly …
reported, but the neural mechanisms that contribute to these outcomes remain poorly …
Next generation genetically encoded fluorescent sensors for serotonin
M Kubitschke, M Müller, L Wallhorn, M Pulin… - Nature …, 2022 - nature.com
We developed a family of genetically encoded serotonin (5-HT) sensors (sDarken) on the
basis of the native 5-HT1A receptor and circularly permuted GFP. sDarken 5-HT sensors are …
basis of the native 5-HT1A receptor and circularly permuted GFP. sDarken 5-HT sensors are …
Opposing contributions of GABAergic and glutamatergic ventral pallidal neurons to motivational behaviors
M Stephenson-Jones, C Bravo-Rivera, S Ahrens… - Neuron, 2020 - cell.com
The ventral pallidum (VP) is critical for invigorating reward seeking and is also involved in
punishment avoidance, but how it contributes to such opposing behavioral actions remains …
punishment avoidance, but how it contributes to such opposing behavioral actions remains …