The success of base editors for the study and treatment of genetic diseases depends on the
ability to deliver them in vivo to the relevant cell types. Delivery via adeno-associated viruses …

Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

In mammals, three major DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …

The proper location and timing of Dnmt1 activation are essential for DNA methylation
maintenance. We demonstrate here that Dnmt1 utilizes two-mono-ubiquitylated histone H3 …

Repression of endogenous retroviruses (ERVs) in mammals involves several epigenetic
mechanisms. Acute loss of the maintenance methyltransferase Dnmt1 induces widespread …

The maintenance of epigenetic characteristics is essential for the normal growth and
development of organisms. The maintenance of DNA methylation is an important way to …

Mammalian DNMT1 is mainly responsible for maintenance DNA methylation that is critical in
maintaining stem cell pluripotency and controlling lineage specification during early …

Alterations in epigenetic landscapes are hallmarks of many complex human diseases, yet, it
is often challenging to assess the underlying mechanisms and causal link with clinical …

Aberrant DNA methylation patterns are a prominent feature of cancer. Methylation of DNA is
mediated by the DNA methyltransferase (DNMT) protein family, which regulates de novo …

DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian
development, and the 5mC profile is regulated by a balance of opposing enzymatic …