i-Motif DNA: structural features and significance to cell biology

H Abou Assi, M Garavís, C González… - Nucleic acids …, 2018 - academic.oup.com
The i-motif represents a paradigmatic example of the wide structural versatility of nucleic
acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held …

i-Motif DNA: structure, stability and targeting with ligands

HA Day, P Pavlou, ZAE Waller - Bioorganic & medicinal chemistry, 2014 - Elsevier
Abstract i-Motifs are four-stranded DNA secondary structures which can form in sequences
rich in cytosine. Stabilised by acidic conditions, they are comprised of two parallel-stranded …

Fluorescent probes for G‐quadruplex structures

BR Vummidi, J Alzeer, NW Luedtke - ChemBioChem, 2013 - Wiley Online Library
Mounting evidence supports the presence of biologically relevant G‐quadruplexes in single‐
cell organisms, but the existence of endogenous G‐quadruplex structures in mammalian …

Fundamental aspects of the nucleic acid i-motif structures

S Benabou, A Aviñó, R Eritja, C González, R Gargallo - Rsc Advances, 2014 - pubs.rsc.org
The i-motif structure is formed in cytosine-rich sequences, its building block being the
cytosine· cytosine+ base pair. This structure is particularly stable at pH values below …

I-motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

JA Brazier, A Shah, GD Brown - Chemical Communications, 2012 - pubs.rsc.org
I-motif formation has been confirmed in a number of gene promoter sequences known to
form G-quadruplex structures. I-motif formation can occur close to physiological temperature …

Methylene blue as a G-quadruplex binding probe for label-free homogeneous electrochemical biosensing

FT Zhang, J Nie, DW Zhang, JT Chen, YL Zhou… - Analytical …, 2014 - ACS Publications
Herein, G-quadruplex sequence was found to significantly decrease the diffusion current of
methylene blue (MB) in homogeneous solution for the first time. Electrochemical methods …

Coexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level

S Dhakal, JD Schonhoft, D Koirala, Z Yu… - Journal of the …, 2010 - ACS Publications
Investigation of i-motif is of high importance to fully understand the biological functions of G
quadruplexes in the context of double-stranded DNA. Whereas single-molecule approaches …

Emerging roles of i-motif in gene expression and disease treatment

X Luo, J Zhang, Y Gao, W Pan, Y Yang, X Li… - Frontiers in …, 2023 - frontiersin.org
As non-canonical nucleic acid secondary structures consisting of cytosine-rich nucleic acids,
i-motifs can form under certain conditions. Several i-motif sequences have been identified in …

Guanine quadruplex structures localize to heterochromatin

RF Hoffmann, YM Moshkin, S Mouton… - Nucleic acids …, 2016 - academic.oup.com
Increasing amounts of data support a role for guanine quadruplex (G4) DNA and RNA
structures in various cellular processes. We stained different organisms with monoclonal …

Duplex-tetraplex equilibria in guanine-and cytosine-rich DNA

TV Chalikian, L Liu, RB Macgregor Jr - Biophysical Chemistry, 2020 - Elsevier
Noncanonical four-stranded DNA structures, including G-quadruplexes and i-motifs, have
been discovered in the cell and are implicated in a variety of genomic regulatory functions …