[HTML][HTML] The ageing brain: molecular and cellular basis of neurodegeneration
Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …
physiological deterioration and increased vulnerability to death. Ageing has also been …
[HTML][HTML] Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts
I Angelopoulos, G Gakis, K Birmpas… - Frontiers in …, 2022 - frontiersin.org
The neural stem cell niche is a key regulator participating in the maintenance, regeneration,
and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons …
and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons …
[PDF][PDF] DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …
[HTML][HTML] Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
Mechanisms underlying phenotypic variation in neurogenetic disorders
JM Burgunder - Nature Reviews Neurology, 2023 - nature.com
Neurological diseases associated with pathogenic variants in a specific gene, or even with a
specific pathogenic variant, can show profound phenotypic variation with regard to symptom …
specific pathogenic variant, can show profound phenotypic variation with regard to symptom …
[PDF][PDF] Neuronal and astrocytic contributions to Huntington's disease dissected with zinc finger protein transcriptional repressors
Huntington's disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT)
resulting in expression of mutant HTT proteins (mHTT) with extended polyglutamine tracts …
resulting in expression of mutant HTT proteins (mHTT) with extended polyglutamine tracts …
[HTML][HTML] Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
M Xu, JY Zhu, XD Liu, MY Luo, NJ Xu - Translational Neurodegeneration, 2021 - Springer
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been
extensively applied to distinguish biological age from chronological age. Aging-related …
extensively applied to distinguish biological age from chronological age. Aging-related …
Aging biomarkers and the brain
Quantifying biological aging is critical for understanding why aging is the primary driver of
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …
[HTML][HTML] Cell rearrangement and oxidant/antioxidant imbalance in huntington's disease
Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the
expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant …
expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant …
Huntington's disease affects mitochondrial network dynamics predisposing to pathogenic mitochondrial DNA mutations
Huntington's disease (HD) predominantly affects the brain, causing a mixed movement
disorder, cognitive decline and behavioural abnormalities. It also causes a peripheral …
disorder, cognitive decline and behavioural abnormalities. It also causes a peripheral …