Background Several studies around the world support the hypothesis that genetic
polymorphisms involved in folate metabolism could be related to the maternal risk for Down …

Down syndrome (DS) is caused by trisomy of chromosome 21 and is associated with
characteristic features of appearance, intellectual impairment to varying degrees, organ …

Background: The presence of polymorphic methylenetetrahydrofolate reductase (MTHFR) in
mothers poses a risk for numerous detrimental outcomes in neonates. The present study …

Objectives: Folates are essential nutrients required for the synthesis of DNA/RNA in cell
division and segregation. Folates are reduced and methylated in the liver with the help of …

Background: Evidence suggests that the dimer configuration of methylenetetrahydrofolate
reductase (MTHFR) enzyme might be destabilized by polymorphisms in monomers at the …

Objective The objective was to investigate the association between maternal
methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms, crucial for DNA …

Background Since MTHFR is the key enzyme in folate metabolism, its reduction can lead to
hyperhomocysteinemia, which can have a negative impact on pregnancy outcome …

Hypertension has relatively large morbidity and mortality rates throughout the world,
including in Indonesia. The prevalence of hypertension tends to be greater in patients with a …

Background Abnormal folate metabolism is a risk factor for DNA hypomethylation and
chromosomal nondisjunction. MTHFR is a candidate gene for folliculogenesis and ovarian …

Primary amenorrhea (PA) is a heterogenous condition with multifactorial etiologies and
cannot be established with single diagnostic criterion. We have attempted to assess several …