STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges
GL Wong, SG Manore, DL Doheny, HW Lo - Seminars in cancer biology, 2022 - Elsevier
Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
Structure and signaling mechanism of Per-ARNT-Sim domains
Per-ARNT-Sim (PAS) domains serve as versatile sensor and interaction modules in signal
transduction proteins. PAS sensors detect chemical and physical stimuli and regulate the …
transduction proteins. PAS sensors detect chemical and physical stimuli and regulate the …
Transcriptional regulation by STAT6
S Goenka, MH Kaplan - Immunologic research, 2011 - Springer
Signal transducer and activator of transcription (STAT) proteins are critical mediators of
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …
bHLH–PAS proteins in cancer
Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are
heterodimeric transcription factors that sense and respond to environmental signals (such as …
heterodimeric transcription factors that sense and respond to environmental signals (such as …
A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome
JR Wagner, JS Brunzelle, KT Forest, RD Vierstra - Nature, 2005 - nature.com
Phytochromes are red/far-red light photoreceptors that direct photosensory responses
across the bacterial, fungal and plant kingdoms. These include photosynthetic potential and …
across the bacterial, fungal and plant kingdoms. These include photosynthetic potential and …
Structure, function, and regulation of STAT proteins
CP Lim, X Cao - Molecular biosystems, 2006 - pubs.rsc.org
The Signal Transducer and Activator of Transcription (STAT) family of proteins was first
discovered in the 1990's as key proteins in cytokine signaling. Since then, the field has …
discovered in the 1990's as key proteins in cytokine signaling. Since then, the field has …
Signaling mechanisms, interaction partners, and target genes of STAT6
D Hebenstreit, G Wirnsberger, J Horejs-Hoeck… - Cytokine & growth factor …, 2006 - Elsevier
Like other members of the signal transducer and activator of transcription (STAT) family of
proteins, STAT6 has a dual role as signaling molecule and transcription factor. STAT6 is …
proteins, STAT6 has a dual role as signaling molecule and transcription factor. STAT6 is …
The LxxLL motif: a multifunctional binding sequence in transcriptional regulation
LxxLL motifs participate in many protein–protein interactions associated with different
aspects of transcriptional regulation. These motifs are present in many transcription factors …
aspects of transcriptional regulation. These motifs are present in many transcription factors …
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation
TLX is a transcription factor that is essential for neural stem cell proliferation and self-
renewal. However, the molecular mechanism of TLX-mediated neural stem cell proliferation …
renewal. However, the molecular mechanism of TLX-mediated neural stem cell proliferation …
The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways
The genetic adaptation of pathogens in host tissue plays a key role in the establishment of
chronic infections. While whole genome sequencing has opened up the analysis of genetic …
chronic infections. While whole genome sequencing has opened up the analysis of genetic …