SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines
The highly transmissible Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) was first detected in late 2021. Initial Omicron waves were …
coronavirus 2 (SARS-CoV-2) was first detected in late 2021. Initial Omicron waves were …
Immune imprinting and next-generation coronavirus vaccines
CQ Huang, S Vishwanath, GW Carnell, ACY Chan… - Nature …, 2023 - nature.com
Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
A Yisimayi, W Song, J Wang, F Jian, Y Yu, X Chen… - Nature, 2024 - nature.com
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19
vaccine compositions. However, immune imprinting induced by vaccination based on the …
vaccine compositions. However, immune imprinting induced by vaccination based on the …
ACE2 binding and antibody evasion in enhanced transmissibility of XBB. 1.5
C Yue, W Song, L Wang, F Jian, X Chen… - The Lancet Infectious …, 2023 - thelancet.com
SARS-CoV-2 subvariants BQ. 1.1 and XBB. 1 have been circulating globally with superior
growth advantages over most omicron mutants (appendix p 5). However, XBB. 1.5, a …
growth advantages over most omicron mutants (appendix p 5). However, XBB. 1.5, a …
Resistance of Omicron subvariants BA. 2.75. 2, BA. 4.6, and BQ. 1.1 to neutralizing antibodies
Convergent evolution of SARS-CoV-2 Omicron BA. 2, BA. 4, and BA. 5 lineages has led to
the emergence of several new subvariants, including BA. 2.75. 2, BA. 4.6. and BQ. 1.1. The …
the emergence of several new subvariants, including BA. 2.75. 2, BA. 4.6. and BQ. 1.1. The …
Enhanced evasion of neutralizing antibody response by Omicron XBB. 1.5, CH. 1.1, and CA. 3.1 variants
P Qu, JN Faraone, JP Evans, YM Zheng, C Carlin… - Cell reports, 2023 - cell.com
Omicron subvariants continuingly challenge current vaccination strategies. Here, we
demonstrate nearly complete escape of the XBB. 1.5, CH. 1.1, and CA. 3.1 variants from …
demonstrate nearly complete escape of the XBB. 1.5, CH. 1.1, and CA. 3.1 variants from …
Molecular fate-mapping of serum antibody responses to repeat immunization
A Schiepers, MFL van't Wout, AJ Greaney, T Zang… - Nature, 2023 - nature.com
The protective efficacy of serum antibodies results from the interplay of antigen-specific B
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
Enhanced transmissibility, infectivity, and immune resistance of the SARS-CoV-2 omicron XBB. 1.5 variant
K Uriu, J Ito, J Zahradnik, S Fujita, Y Kosugi… - The Lancet infectious …, 2023 - thelancet.com
Enhanced transmissibility, infectivity, and immune resistance of the SARS-CoV-2 omicron
XBB.1.5 variant - The Lancet Infectious Diseases Skip to Main Content Advertisement The …
XBB.1.5 variant - The Lancet Infectious Diseases Skip to Main Content Advertisement The …
Predicting the efficacy of variant-modified COVID-19 vaccine boosters
Booster vaccination for the prevention of Coronavirus Disease 2019 (COVID-19) is required
to overcome loss of protection due to waning immunity and the spread of novel severe acute …
to overcome loss of protection due to waning immunity and the spread of novel severe acute …
[HTML][HTML] Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA. 2.86 and FLip variants
Evolution of SARS-CoV-2 requires the reassessment of current vaccine measures. Here, we
characterized BA. 2.86 and XBB-derived variant FLip by investigating their neutralization …
characterized BA. 2.86 and XBB-derived variant FLip by investigating their neutralization …