cAMP signaling in cancer: a PKA-CREB and EPAC-centric approach
Cancer is one of the most common causes of death globally. Despite extensive research
and considerable advances in cancer therapy, the fundamentals of the disease remain …
and considerable advances in cancer therapy, the fundamentals of the disease remain …
Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
Sulfonylureas: a new look at old therapy
PM Thulé, G Umpierrez - Current diabetes reports, 2014 - Springer
Sulfonylurea compounds were the first available oral antidiabetic agents and they remain an
important tool in our quest for optimal glucose control. The sulfonylureas stimulate the …
important tool in our quest for optimal glucose control. The sulfonylureas stimulate the …
Cyclic AMP dynamics in the pancreatic β-cell
A Tengholm - Upsala journal of medical sciences, 2012 - Taylor & Francis
Insulin secretion from pancreatic β-cells is tightly regulated by glucose and other nutrients,
hormones, and neural factors. The exocytosis of insulin granules is triggered by an elevation …
hormones, and neural factors. The exocytosis of insulin granules is triggered by an elevation …
Isoform-specific antagonists of exchange proteins directly activated by cAMP
T Tsalkova, FC Mei, S Li… - Proceedings of the …, 2012 - National Acad Sciences
The major physiological effects of cAMP in mammalian cells are transduced by two
ubiquitously expressed intracellular cAMP receptors, protein kinase A (PKA) and exchange …
ubiquitously expressed intracellular cAMP receptors, protein kinase A (PKA) and exchange …
Optical control of insulin release using a photoswitchable sulfonylurea
J Broichhagen, M Schönberger, SC Cork… - Nature …, 2014 - nature.com
Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM).
Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost …
Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost …
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4 (3H)-one derivatives as potential PPARγ and SUR agonists
Peroxisome proliferator-activated receptor gamma (PPARγ) and sulfonylurea receptor
(SUR) play crucial roles in management of type-2 diabetes mellitus. In this study, a series of …
(SUR) play crucial roles in management of type-2 diabetes mellitus. In this study, a series of …
Design, molecular docking, synthesis, anticancer and anti-hyperglycemic assessments of thiazolidine-2, 4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR …
Newly designed thiazolidine-2, 4-diones 3–7a–c were synthesized, and their anticancer
activities were screened against three cancer lines. They showed potent activities against …
activities were screened against three cancer lines. They showed potent activities against …
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPARγ and SUR agonists
In our effort to develop potent anti-hyperglycemic agents with potential agonistic activities
toward PPARγ and SUR, three novel series of quinoxaline derivatives bearing sulfonylurea …
toward PPARγ and SUR, three novel series of quinoxaline derivatives bearing sulfonylurea …