Turbocharging synaptic transmission
JE Rothman, K Grushin, M Bera, F Pincet - FEBS letters, 2023 - Wiley Online Library
Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea
that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) …
that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) …
Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles
Munc13-1 is essential for vesicle docking and fusion at the active zone of synapses. Here,
we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich …
we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich …
Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates fusion pore fate at the release site
BR Bhaskar, L Yadav, M Sriram, K Sanghrajka… - Nature …, 2024 - nature.com
The regulated release of chemical messengers is crucial for cell-to-cell communication;
abnormalities in which impact coordinated human body function. During vesicular secretion …
abnormalities in which impact coordinated human body function. During vesicular secretion …
Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers
F Li, J Coleman, L Redondo-Morata… - Communications …, 2024 - nature.com
Abstract Synaptotagmin-1 (Syt-1) self-assembles into ring-like oligomers, and genetic and
biochemical evidence suggest that oligomerization is needed to clamp synaptic vesicles and …
biochemical evidence suggest that oligomerization is needed to clamp synaptic vesicles and …