Advances and highlights in biomarkers of allergic diseases

I Ogulur, Y Pat, O Ardicli, E Barletta, L Cevhertas… - Allergy, 2021 - Wiley Online Library
During the past years, there has been a global outbreak of allergic diseases, presenting a
considerable medical and socioeconomical burden. A large fraction of allergic diseases is …

Novel insights into atopic dermatitis

CF Schuler IV, AC Billi, E Maverakis, LC Tsoi… - Journal of Allergy and …, 2023 - Elsevier
Recent research into the pathophysiology and treatment of atopic dermatitis (AD) has shown
notable progress. An increasing number of aspects of the immune system are being …

Dysregulation of the epithelial barrier by environmental and other exogenous factors

Y Mitamura, I Ogulur, Y Pat, AO Rinaldi… - Contact …, 2021 - Wiley Online Library
The “epithelial barrier hypothesis” proposes that the exposure to various epithelial barrier–
damaging agents linked to industrialization and urbanization underlies the increase in …

Mechanisms of microbe-immune system dialogue within the skin

N Lunjani, S Ahearn-Ford, FS Dube, C Hlela… - Genes & …, 2021 - nature.com
The prevalence and severity of dermatological conditions such as atopic dermatitis have
increased dramatically during recent decades. Many of the factors associated with an …

Skin microbiome and its association with host cofactors in determining atopic dermatitis severity

L Rauer, M Reiger, M Bhattacharyya… - Journal of the …, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is a heterogeneous, chronic inflammatory skin disease
linked to skin microbiome dysbiosis with reduced bacterial diversity and elevated relative …

Real‐world efficacy and safety of dupilumab in Chinese patients with atopic dermatitis: a single‐centre, prospective, open‐label study

C Gu, Y Wu, Y Luo, S Wang, H Yin… - Journal of the …, 2022 - Wiley Online Library
Background Dupilumab, an antibody against interleukin‐4 receptor α, has demonstrated
elegant efficacy and safety profiles in patients with moderate‐to‐severe atopic dermatitis …

Staphylococcal communities on skin are associated with atopic dermatitis and disease severity

SM Edslev, CM Olesen, LB Nørreslet, AC Ingham… - Microorganisms, 2021 - mdpi.com
The skin microbiota of atopic dermatitis (AD) patients is characterized by increased
Staphylococcus aureus colonization, which exacerbates disease symptoms and has been …

A new era of atopic eczema research: advances and highlights

C Hülpüsch, AB Weins, C Traidl‐Hoffmann, M Reiger - Allergy, 2021 - Wiley Online Library
Atopic eczema (AE) is an inflammatory skin disease with involvement of genetic,
immunological and environmental factors. One hallmark of AE is a skin barrier disruption on …

Transcriptome‐based identification of novel endotypes in adult atopic dermatitis

A Lefèvre‐Utile, M Saichi, P Oláh, M Delord, B Homey… - Allergy, 2022 - Wiley Online Library
Background Atopic dermatitis (AD) is a frequent and heterogeneous inflammatory skin
disease, for which personalized medicine remains a challenge. High‐throughput …

Microenvironmental host–microbe interactions in chronic inflammatory skin diseases

L Bay, GB Jemec, HC Ring - Apmis, 2024 - Wiley Online Library
Several microbiome studies have recently demonstrated microbial dysbiosis in various
chronic inflammatory skin diseases, and it is considered an important role in the …