Metabolic therapy: a new paradigm for managing malignant brain cancer
Little progress has been made in the long-term management of glioblastoma multiforme
(GBM), considered among the most lethal of brain cancers. Cytotoxic chemotherapy …
(GBM), considered among the most lethal of brain cancers. Cytotoxic chemotherapy …
[HTML][HTML] Metabolic management of brain cancer
Malignant brain tumors are a significant health problem in children and adults. Conventional
therapeutic approaches have been largely unsuccessful in providing long-term …
therapeutic approaches have been largely unsuccessful in providing long-term …
[HTML][HTML] Epidemiology of glial and non-glial brain tumours in Europe
E Crocetti, A Trama, C Stiller, A Caldarella… - European journal of …, 2012 - Elsevier
To the central nervous system (CNS) belong a heterogeneous group of glial and non glial
rare cancers. The aim of the present study was to estimate the burden (incidence …
rare cancers. The aim of the present study was to estimate the burden (incidence …
Pseudoprogression of glioblastoma after chemo-and radiation therapy: diagnosis by using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging …
S Gahramanov, LL Muldoon, CG Varallyay, X Li… - Radiology, 2013 - pubs.rsna.org
Purpose To compare gadoteridol and ferumoxytol for measurement of relative cerebral
blood volume (rCBV) in patients with glioblastoma multiforme (GBM) who showed …
blood volume (rCBV) in patients with glioblastoma multiforme (GBM) who showed …
Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma
PURPOSE: To evaluate the pattern of failure after limited margin radiotherapy for
glioblastoma. METHODS AND MATERIALS: We analyzed 62 consecutive patients with …
glioblastoma. METHODS AND MATERIALS: We analyzed 62 consecutive patients with …
Phase II study of PX-866 in recurrent glioblastoma
MW Pitz, EA Eisenhauer, MV MacNeil… - Neuro …, 2015 - academic.oup.com
Background Glioblastoma (GBM) is the most aggressive malignancy of the central nervous
system in adults. Increased activity of the phosphatidylinositol-3-OH kinase (PI3K) signal …
system in adults. Increased activity of the phosphatidylinositol-3-OH kinase (PI3K) signal …
Canadian recommendations for the treatment of recurrent or progressive glioblastoma multiforme
Abstract Recommendation 1: Multidisciplinary Approach: To optimize treatment outcomes,
the management of patients with recurrent glioblastoma should be individualized and …
the management of patients with recurrent glioblastoma should be individualized and …
Brain fatty acid-binding protein and ω-3/ω-6 fatty acids: mechanistic insight into malignant glioma cell migration
Malignant gliomas (MG) are highly infiltrative tumors that consistently recur despite
aggressive treatment. Brain fatty acid-binding protein (FABP7), which binds …
aggressive treatment. Brain fatty acid-binding protein (FABP7), which binds …
Pseudoprogression following chemoradiotherapy for glioblastoma multiforme
Purpose: Pseudoprogression (psPD) is now recognised following radiotherapy with
concurrent temozolomide (RT/TMZ) for glioblastoma multiforme (GBM). The aim of this study …
concurrent temozolomide (RT/TMZ) for glioblastoma multiforme (GBM). The aim of this study …
Neurological adverse effects caused by cytotoxic and targeted therapies
D Schiff, PY Wen, MJ Van Den Bent - Nature Reviews Clinical …, 2009 - nature.com
Historically, body tissues with a high rate of cell turnover, such as the bone marrow, have
been most susceptible to chemotherapy-induced damage. The widespread use of …
been most susceptible to chemotherapy-induced damage. The widespread use of …