Stress granule subtypes: an emerging link to neurodegeneration
Abstract Stress Granules (SGs) are membraneless cytoplasmic RNA granules, which
contain translationally stalled mRNAs, associated translation initiation factors and multiple …
contain translationally stalled mRNAs, associated translation initiation factors and multiple …
[HTML][HTML] Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs
J Hawrot, S Imhof, BJ Wainger - Neurobiology of disease, 2020 - Elsevier
Amyotrophic lateral sclerosis (ALS) is an aggressive and uniformly fatal degenerative
disease of the motor nervous system. In order to understand underlying disease …
disease of the motor nervous system. In order to understand underlying disease …
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
M Aikio, HM Odeh, HJ Wobst, BL Lee, Ú Chan… - Cell Reports, 2025 - cell.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder typically
characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms …
characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms …
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the …
The RNA-binding and-processing protein TAR DNA-binding protein 43 (TDP-43) is heavily
linked to the underlying causes and pathology of neurodegenerative diseases such as …
linked to the underlying causes and pathology of neurodegenerative diseases such as …
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
J Chadchankar, V Korboukh, LC Conway, HJ Wobst… - PLoS …, 2019 - journals.plos.org
USP14 is a cysteine protease deubiquitinase associated with the proteasome and plays
important catalytic and allosteric roles in proteasomal degradation. USP14 inhibition has …
important catalytic and allosteric roles in proteasomal degradation. USP14 inhibition has …
[HTML][HTML] The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl− extrusion
N Cho, G Kontou, JL Smalley, C Bope, J Dengler… - Iscience, 2024 - cell.com
LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a
scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk …
scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk …