Three-dimensional (3D) tissue culture models have an invaluable role in tumour biology
today providing some very important insights into cancer biology. As well as increasing our …

Abstract Three-dimensional (3D) in vitro breast tumour models have an invaluable role in
tumour biology today providing some very important insights into breast cancer. As well as …

Establishment of a human model of the blood‐brain barrier has proven to be a difficult goal.
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …

Mesenchymal stem cells (MSC) comprise a promising tool for cellular therapy. These cells
are usually culture expanded prior to their application. However, a precise molecular …

Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo
replicative senescence characterized by cell enlargement, loss of differentiation potential …

The regenerative potential diminishes with age and this has been ascribed to functional
impairments of adult stem cells. Cells in culture undergo senescence after a certain number …

Objective Development of proteinuria in lupus nephritis (LN) is associated with podocyte
dysfunction. The NLRP3 inflammasome has been implicated in the pathogenesis of LN. The …

The in vitro production of meat is probably feasible with existing tissue engineering
techniques and may offer health and environmental advantages by reducing environmental …

Yes-associated protein (YAP) has been shown to positively regulate p53 family members
and to be negatively regulated by the AKT proto-oncogene product in promoting apoptosis …

The Notch signaling pathway and the delta-like 4 ligand (DLL4) play key roles in embryonic
vascular development. Many of the pathways involved in embryonic vascular development …