Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …

The molecular clock maintains energy constancy by producing circadian oscillations of rate-
limiting enzymes involved in tissue metabolism across the day and night,,. During periods of …

The transcriptional regulatory networks that specify and maintain human tissue diversity are
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation …

The β‐site APP cleaving enzymes 1 and 2 (BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …

Broad heterogeneity in pancreatic β-cell function and morphology has been widely reported.
However, determining which components of this cellular heterogeneity serve a diabetes …

Background Type 2 diabetes shows evidence of underlying heterogeneity. No studies have
assessed whether different causes for diabetes change the response to oral hypoglycaemic …

Glycolysis, a central metabolic pathway, harbors evolutionary conserved enzymes that
modulate and potentially shift the cellular metabolism on requirement. Pyruvate kinase …

The pathways that control insulin secretion and regulate pancreatic β-cell mass are crucial
in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a …

The specialized endocrine and exocrine cells of the pancreas originally derive from a pool of
apparently identical cells in the early gut endoderm. Serial changes in their gene expression …