Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020
This review fully describes the coronavirus 3CL pro peptidomimetic inhibitors and
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …
[HTML][HTML] Artificial intelligence approach fighting COVID-19 with repurposing drugs
YY Ke, TT Peng, TK Yeh, WZ Huang, SE Chang… - Biomedical journal, 2020 - Elsevier
Background The ongoing COVID-19 pandemic has caused more than 193,825 deaths
during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic …
during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic …
In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2's Main Protease
Currently, the new coronavirus disease 2019 (COVID-19) is a global pandemic without any
well-calibrated treatment. To inactivate the SARS-CoV-2 virus that causes COVID-19, the …
well-calibrated treatment. To inactivate the SARS-CoV-2 virus that causes COVID-19, the …
[HTML][HTML] Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection
KH Chiow, MC Phoon, T Putti, BKH Tan… - Asian Pacific journal of …, 2016 - Elsevier
Objective To evaluate the in vitro activities of the ethyl acetate (EA) fraction of Houttuynia
cordata (H. cordata) Thunb.(Saururaceae) and three of its constituent flavonoids (quercetin …
cordata (H. cordata) Thunb.(Saururaceae) and three of its constituent flavonoids (quercetin …
Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches
M Gioia, C Ciaccio, P Calligari, G De Simone… - Biochemical …, 2020 - Elsevier
In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus
Disease COVID-19), due to a new Coronavirus strain (ie, SARS-CoV-2), emerged in the …
Disease COVID-19), due to a new Coronavirus strain (ie, SARS-CoV-2), emerged in the …
Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
R Ramajayam, KP Tan, HG Liu, PH Liang - Bioorganic & medicinal …, 2010 - Elsevier
A series of pyrazolone compounds as possible SARS-CoV 3CL protease inhibitors were
designed, synthesized, and evaluated by in vitro protease assay using fluorogenic substrate …
designed, synthesized, and evaluated by in vitro protease assay using fluorogenic substrate …
[PDF][PDF] Corona virus drugs–a brief overview of past, present and future
SH Basha - Journal of PeerScientist, 2020 - peerscientist.com
A novel coronavirus (CoV), SARS-CoV-2 surfaced in late 2019 in Wuhan, China. SARS-CoV-
2, unlike previously identified coronaviruses responsible for severe acute respiratory …
2, unlike previously identified coronaviruses responsible for severe acute respiratory …
Synthetic and computational efforts towards the development of peptidomimetics and small-molecule SARS-CoV 3CLpro inhibitors
Abstract Severe Acute Respiratory Syndrome (SARS) is a severe febrile respiratory disease
caused by the beta genus of human coronavirus, known as SARS-CoV. Last year, 2019-n …
caused by the beta genus of human coronavirus, known as SARS-CoV. Last year, 2019-n …
Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
R Ramajayam, KP Tan, HG Liu, PH Liang - Bioorganic & medicinal …, 2010 - Elsevier
A series of 2-(benzylthio)-6-oxo-4-phenyl-1, 6-dihydropyrimidine as SARS-CoV 3CL
protease inhibitors were developed and their potency was evaluated by in vitro protease …
protease inhibitors were developed and their potency was evaluated by in vitro protease …