Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …

Insulin, a key peptide hormone that conjointly with its receptor regulates blood glucose
levels, is used as the major means to treat diabetes. This therapeutic hormone may undergo …

Globally, millions of diabetic patients require daily life-saving insulin injections. Insulin heat-
lability and fibrillation pose significant challenges, especially in parts of the world without …

Insulin, a 51-residue peptide hormone, is an intrinsically amyloidogenic peptide, forming
amyloid fibrils in vitro. In the secretory granules, insulin is densely packed together with Zn …

Insulin aggregation has pronounced pharmaceutical implications and biological importance.
Deposition of insulin aggregates is associated with type II diabetes and instability of …

Purpose To investigate insulin fibrillation under accelerated stress conditions in the
presence of a novel excipient, the molecular chaperone α-crystallin, in comparison with …

The kinetics of dithiothreitol (DTT)-induced aggregation of human recombinant insulin and
the effect of α-crystallin, a representative of the family of small heat shock proteins, on the …

Static and dynamic light scattering were used to investigate the effects of L‐arginine,
commonly used to inhibit protein aggregation, on the initial aggregation kinetics of solutions …

The Schiff base containing imine and phenoilc–OH groups can act as a potent inhibitor
against Cu 2+-mediated aggregation of γ-crystallin and it had demonstrated positive …

We have developed a multiwell-based protein aggregation assay to study the kinetics of
insulin adsorption and aggregation on hydrophobic surfaces and to investigate the …