Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Many DNA-processing enzymes have been shown to contain a [4Fe4S] cluster, a common
redox cofactor in biology. Using DNA electrochemistry, we find that binding of the DNA …

Iron-sulfur (Fe-S) clusters are unique, redox-active co-factors ubiquitous throughout cellular
metabolism. Fe-S cluster synthesis, trafficking, and coordination result from highly …

Many DNA replication and DNA repair enzymes have been found to carry [4Fe4S] clusters.
The major leading strand polymerase, DNA polymerase ε (Pol ε) from Saccharomyces …

Metabolism and DNA replication are the two most fundamental biological functions in life.
The catabolic branch of metabolism breaks down nutrients to produce energy and …

The marine thermophilic archaeon Nanoarchaeum equitans possesses a monomeric
primase encompassing the conserved domains of the small catalytic and the large …

Recent advances have led to numerous landmark discoveries of [4Fe4S] clusters
coordinated by essential enzymes in repair, replication, and transcription across all domains …

B-type eukaryotic polymerases contain a [4Fe-4S] cluster in their C-terminus domain, whose
role is not fully understood yet. Among them, DNA polymerase delta (Polδ) plays an …

Generation of daughter strands during DNA replication requires the action of DNA primase
to synthesize an initial short RNA primer on the single-stranded DNA template. Primase is a …

Iron–sulfur (Fe-S) clusters are essential cofactors found in many proteins in the
mitochondria, cytosol, and nucleus of the cell. These versatile cofactors may undergo …