Introduction VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome
is a recently described, late-onset, acquired autoinflammatory disorder caused by mutations …

Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Abstract VEXAS (Vacuoles, E1 enzyme, X‐linked, Autoinflammatory, Somatic) syndrome is a
newly identified disease caused by somatic alterations in UBA1 which produce a recalcitrant …

Abstract Background Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS)
syndrome is a recently recognized multisystem disorder caused by somatic mutations in the …

VEXAS is a prototypic hemato‐inflammatory disease combining rheumatologic and
hematologic disorders in a molecularly defined nosological entity. In this nationwide study …

VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a novel entity
manifesting with a multiplicity of clinical features. Somatic mutations of the UBA1 gene in …

The recently discovered VEXAS syndrome is caused by the clonal expansion of
hematopoietic stem or progenitor cells with acquired mutations in UBA1 gene, which …

Somatic mutations of the X-linked UBA1 gene in myeloid progenitors constitute the
molecular underpinnings of VEXAS, typically occurring in men during the sixth decade of …

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome is a newly recognized,
acquired autoinflammatory disorder with broad systemic implications and a poor global …

Approximately one-third of patients with myeloid disorders like myelodysplastic syndrome
(MDS) and chronic myelomonocytic leukemia (CMML) exhibit inflammatory and autoimmune …