A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

Abstract Traditional Chinese Medicine (TCM) has been extensively used as a mainstay for
treating various pathologies. Combing the pharmacology and systems biology approaches …

In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly
occurs, and ex vivo models support that some of these bacteria can trigger host …

Protein interaction networks and protein compartmentalization underlie all signaling and
regulatory processes in cells. Enzyme-catalyzed proximity labeling (PL) has emerged as a …

Respiratory failure is associated with increased mortality in COVID-19 patients. There are no
validated lower airway biomarkers to predict clinical outcome. We investigated whether …

Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

The major cell classes of the brain differ in their developmental processes, metabolism,
signaling, and function. To better understand the functions and interactions of the cell types …

With the emergence of RNA sequencing (RNA-seq) technologies, RNA-based biomolecules
hold expanded promise for their diagnostic, prognostic and therapeutic applicability in …

Summary N 6-methyladenosine (m 6 A) and N 6, 2′-O-dimethyladenosine (m 6 Am) are
abundant mRNA modifications that regulate transcript processing and translation. The role …

Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …