The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

Scorpion venoms have proven to be excellent sources of antimicrobial agents. However,
although many of them have been functionally characterized, they remain underutilized as …

Complementary to endocytosis, cell-penetrating peptides (CPPs) at high concentrations can
penetrate the cell membrane in a direct way, which further makes CPPs popular candidates …

The fusion peptide (FP) domain is necessary for the fusogenic activity of spike proteins in a
variety of enveloped viruses, allowing the virus to infect the host cell, and is the only part of …

Lysophospholipids (LPLs) and host defense peptides (HDPs) are naturally occurring
membrane-active agents that disrupt key membrane properties, including the hydrocarbon …

Sticholysins are pore-forming toxins of biomedical interest and represent a prototype of
proteins acting through the formation of protein-lipid or toroidal pores. Peptides spanning the …

Lipid models such as monolayers, vesicles, and planar bilayers have been developed to
better understand the physicochemical and biophysical properties of biological membranes …

Polyhexamethylene guanidine (PHMG) is a cationic antimicrobial oligomer that has been
used prevalently over the past few decades. However, due to the lack of inhalation toxicity …

Transmembrane pores play an important role in various cell processes. However, the
detailed structures of these pores and their influence on the membrane properties remain …

In this work, we performed coarse-grained molecular dynamics (CGMD) simulations of G3,
G4, and G5 polyamidoamine (PAMAM) dendrimers grafting with fatty acid (FTA) chains. The …