Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an
important regulator of the thermogenic capacity of brown adipocytes. Adipose-specific …

Mitochondria are central in retinal cell function and survival and they perform functions that
are critical to cell function. Retinal neurons have high energy requirements, since large …

Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …

The fatty acid composition of photoreceptor outer segment (POS) phospholipids diverges
from other membranes, being highly enriched in polyunsaturated fatty acids (PUFAs). The …

Peroxisomes are membrane-bound organelles involved in many metabolic pathways and
essential for human health. They harbor a large number of enzymes involved in the different …

Sterol regulatory-element binding proteins (SREBPs) are classical regulators of cellular lipid
metabolism in the kidney and other tissues. SREBPs are currently recognized as versatile …