Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Epigenetic signals are responsible for the establishment, maintenance, and reversal of
metastable transcriptional states that are fundamental for the cell's ability to “remember” past …

Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …

In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …

ABSTRACT Heat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription
factor that coordinates stress-induced transcription and directs versatile physiological …