Perineural invasion (PNI) is the process of neoplastic invasion of peripheral nerves and is
considered to be the fifth mode of cancer metastasis. PNI has been detected in head and …

Since metastasis accounts for the majority of cancer morbidity and mortality, attempts are
focused to block metastasis and metastasis initiating cellular programs. It is generally …

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a
critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in …

Lung adenocarcinoma (LUAD) is the most common malignant subtype of lung cancer (LC).
miR-200 family is one of the prime miR regulators of epithelial-mesenchymal transition …

Tumor-initiating cells (TICs) are a rare sub-population of cells within the bulk of a tumor that
are major contributors to tumor initiation, metastasis, and chemoresistance. TICs have a …

Background Gastric cancer (GC) is a significant cancer-related cause of death worldwide.
GC's most used chemotherapeutic regimen is based on platinum drugs such as cisplatin …

Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive solid
tumors with a dismal prognosis and an increasing incidence. At the time of diagnosis, more …

Immune cell migration is required for the development of an effective and robust immune
response. This elegant process is regulated by both cellular and environmental factors, with …

Intracellular pH (pHi) regulation is a challenge for the exocrine pancreas, where the luminal
secretion of bicarbonate-rich fluid is accompanied by interstitial flows of acid. This acid–base …

Background Microglia, brain resident macrophages, play multiple roles in maintaining
homeostasis, including immunity, surveillance, and protecting the central nervous system …