Development is a complex process regulated both by genetic and epigenetic and
environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

Neurodevelopmental models of schizophrenia that identify longitudinal precursors of illness
have been of great heuristic importance focusing most etiologic research over the past two …

A large portion of the eukaryotic genome is transcribed as noncoding RNAs (ncRNAs).
While once thought of primarily as “junk,” recent studies indicate that a large number of …

Schizophrenia is a complex disorder, where family, twin and adoption studies have been
demonstrating a high heritability of the disease and that this disease is not simply defined by …

A strong candidate gene for schizophrenia and major mental disorders, disrupted-in-
schizophrenia 1 (DISC1) was first described in a large Scottish family in which a balanced …

The progressive maturation and functional plasticity of the nervous system in health and
disease involve a dynamic interplay between the transcriptome and the environment. There …

Context Chromosome 1q42 is among several genomic regions showing replicated evidence
of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this …

According to current paradigms, various risk factors, such as genetic mutations, oxidative
stress, neural network dysfunction, and abnormal protein degradation, contribute to the …

Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental
illness, but the mechanism of the clinical association is unknown. We searched for DISC1 …