Proteases have an important role in many signalling pathways, and represent potential drug
targets for diseases ranging from cardiovascular disorders to cancer, as well as for …

Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and
are distantly related to metazoan caspases. Although metacaspases share structural …

Small-molecule target identification is a vital and daunting task for the chemical biology
community as well as for researchers interested in applying the power of chemical genetics …

Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …

Caspases are proteases at the heart of networks that govern apoptosis and inflammation.
The past decade has seen huge leaps in understanding the biology and chemistry of the …

We developed a simple and rapid multiplex substrate-profiling method to reveal the
substrate specificity of any endo-or exopeptidase using liquid chromatography–tandem …

In recent years, procedures for selecting the N-terminal peptides of proteins with analysis by
mass spectrometry have been established to characterize protease-mediated cleavage and …

Proteolysis is a critical post-translational modification for regulation of cellular processes.
Our lab has previously developed a technique for specifically labeling unmodified protein N …

This review aims to highlight the proteases required for regulated cell death mechanisms in
animals and plants. The aim is to be incisive, and not inclusive of all the animal proteases …

As proteome-wide C-terminal sequence analysis has been largely intractable, we
developed a polymer-based enrichment approach to profile protein C-terminal peptides by …