Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Childhood obesity is, according to the WHO, one of the most serious challenges of the 21st
century. More than 100 million children have obesity today. Already during childhood …

Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

Microvascular and metabolic physiology are tightly linked. This Perspective reviews
evidence that 1) the relationship between hyperglycemia and microvascular dysfunction …

Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has
gained popularity in recent years in the context of neurological diseases (NDs). The …

Introduction The impact of prediabetes and diabetes on cognitive decline and the potential
underlying mechanisms remain unclear. We investigated whether prediabetes and diabetes …

Importance Dementia risk may be attenuated by physical activity (PA); however, the specific
activity levels optimal for dementia prevention are unclear. Moreover, most older adults are …

Introduction It is unknown whether vascular and metabolic diseases assessed in early
adulthood are associated with Alzheimer's disease (AD) later in life. Methods Association of …