DNA damage is typically caused during cell growth by DNA replication stress or exposure to
endogenous or external toxins. The accumulation of damaged DNA causes genomic …

Ataxia-telangiectasia mutated (ATM) was first discovered in patients with AT (ataxia
telangiectasia), which is characteristic with cerebellar degeneration, immunodeficiency …

Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

The protein kinase ataxia telangiectasia mutated (ATM) is a constituent of the
phosphatidylinositol 3-kinase-related kinase (PIKK) family, exerting a pivotal influence on …

Diagnoses of CNS malignancies in the primary and metastatic setting have significantly
advanced in the last decade with the advent of molecular pathology. Using a combination of …

Macrophages represent an important component of the innate immune system. Under
physiological conditions, macrophages, which are essential phagocytes, maintain a …

Metastatic brain tumors, also called brain metastasis (BM), represent a challenging
complication of advanced tumors. Tumors that commonly metastasize to the brain include …

Genomic instability is often caused by deficiencies in DNA damage repair pathways, making
therapeutic targeting of DDR beneficial for cancer patients with specific DDR functions. ATM …

The potential treatment option of targeting DNA methyltransferase 1 (DNMT1) has been
explored, but further investigation is required to assess the efficacy of combination therapy in …

Purpose Small cell lung cancer (SCLC) is an aggressive and lethal form of lung cancer and
the overall 5-year survival (OS) for patients is a dismal 7%. Radiation therapy (RT) provides …