Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Coronary artery disease (CAD) is one of the major cardiovascular diseases affecting the
global human population. This disease has been proved to be the major cause of death in …

To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …

Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and
environmental factors. Ninety-seven genetic risk loci have been identified to date, but the …

Background Both genetic and lifestyle factors contribute to individual-level risk of coronary
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle …

Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular
mechanism in human disease remains obscure. Here we show that circular antisense non …

Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is
largely based on genome-wide association study (GWAS) analysis of common SNPs …