Sorting (or isolation) and manipulation of rare cells with high recovery rate and purity are of
critical importance to a wide range of physiological applications. In the current paper, we …

This paper presents a comprehensive review of the development of the optical stretcher, a
powerful optofluidic device for single cell mechanical study by using optical force induced …

The physiological functions of human red blood cells (RBCs) play a crucial role to human
health and are greatly influenced by their mechanical properties. Any alteration of the cell …

Laser trapping with optical tweezers is a noninvasive manipulation technique and has
received increasing attentions in biological applications. Understanding forces exerted on …

Human embryonic stem cells (hESC) and hESC-derived cardiomyocytes (hESC-CM) hold
great promise for the treatment of cardiovascular diseases. However the mechanobiological …

Research and biomedical applications in cell surgery require transportation and rotation of
biological cells. In these cell manipulation tasks, the cell of interest must be translated and …

A computational study of the blood flow in a stenosed microvessel is presented using
coupled discrete ghost-cell and continuous-forcing immersed boundary methods. This study …

Background Cytoskeleton is a highly dynamic network that helps to maintain the rigidity of a
cell, and the mechanical properties of a cell are closely related to many cellular functions …

Large deformability of erythrocytes in microvasculature is a prerequisite to realize smooth
circulation. We develop a novel tool for the three-step “Catch-Load-Launch” manipulation of …

Microinjection has been demonstrated to be an effective technique to introduce foreign
materials into biological cells. Despite the advance, whether cell injection can be used to …