The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial
peptides (AMPs). Recent work has shown that these molecules have great potential not only …

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane.
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …

The bacterial cytoplasmic membrane is a major inhibitory target for antimicrobial
compounds. Commonly, although not exclusively, these compounds unfold their …

Short antimicrobial peptides rich in arginine (R) and tryptophan (W) interact with
membranes. To learn how this interaction leads to bacterial death, we characterized the …

Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the
market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections …

Cold atmospheric-pressure plasmas are currently in use in medicine as surgical tools and
are being evaluated for new applications, including wound treatment and cosmetic care. The …

Cyclic β-sheet decapeptides from the tyrocidine group and the homologous gramicidin S
were the first commercially used antibiotics, yet it remains unclear exactly how they kill …

Highlights•B. subtilis encodes seven ECF σ factors that activate cell envelope stress
responses (CESR).•σ W coordinates resistance to bacteriocins and membrane-active …

The synthetic cyclic hexapeptide cWFW (cyclo (RRRWFW)) has a rapid bactericidal activity
against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has …