Recent advances in CD8+ regulatory T cell research
Y Yu, X Ma, R Gong, J Zhu, L Wei… - Oncology …, 2018 - spandidos-publications.com
Various subgroups of CD8+ T lymphocytes do not only demonstrate cytotoxic effects, but
also serve important regulatory roles in the body's immune response. In particular, CD8+ …
also serve important regulatory roles in the body's immune response. In particular, CD8+ …
The HIV-1 latent reservoir is largely sensitive to circulating T cells
HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral
variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus …
variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus …
Inferring the multiplicity of founder variants initiating HIV-1 infection: a systematic review and individual patient data meta-analysis
Background HIV-1 infections initiated by multiple founder variants are characterised by a
higher viral load and a worse clinical prognosis than those initiated with single founder …
higher viral load and a worse clinical prognosis than those initiated with single founder …
Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression
DC Mónaco, DA Dilernia, A Fiore-Gartland… - Journal of Experimental …, 2016 - rupress.org
HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we
evaluate the impact on viral control and disease progression of transmitted polymorphisms …
evaluate the impact on viral control and disease progression of transmitted polymorphisms …
Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants
J Nazziwa, SM Andrews, MM Hou, CAW Bruhn… - Journal of …, 2024 - Am Soc Microbiol
Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been
associated with reduced control of HIV-1 replication in adults. However, less is known about …
associated with reduced control of HIV-1 replication in adults. However, less is known about …
Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection
K Reddy, GQ Lee, N Reddy, TJB Chikowore, K Baisley… - medRxiv, 2024 - medrxiv.org
Background Persisting HIV reservoir viruses in resting CD4 T cells and other cellular
subsets are the main barrier to cure efforts. Antiretroviral therapy (ART) intensification by …
subsets are the main barrier to cure efforts. Antiretroviral therapy (ART) intensification by …
Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical …
P Madlala, Z Mkhize, S Naicker, SP Khathi… - PLoS …, 2023 - journals.plos.org
A genetic bottleneck is a hallmark of HIV-1 transmission such that only very few viral strains,
termed transmitted/founder (T/F) variants establish infection in a newly infected host …
termed transmitted/founder (T/F) variants establish infection in a newly infected host …
Mother-to-child HIV transmission bottleneck selects for consensus virus with lower gag-protease-driven replication capacity
VL Naidoo, JK Mann, C Noble, E Adland… - Journal of …, 2017 - Am Soc Microbiol
In the large majority of cases, HIV infection is established by a single variant, and
understanding the characteristics of successfully transmitted variants is relevant to …
understanding the characteristics of successfully transmitted variants is relevant to …
Convergent evolution as an indicator for selection during acute HIV-1 infection
F Bertels, KJ Metzner… - Peer Community …, 2021 - peercommunityjournal.org
Convergent evolution describes the process of di erent populations acquiring similar
phenotypes or genotypes. Complex organisms with large genomes only rarely and only …
phenotypes or genotypes. Complex organisms with large genomes only rarely and only …
Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control
Background Despite the low level of viral replication in HIV controllers (HICs), studies have
reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in …
reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in …