Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

Drug discovery and development (DDD) is a highly complex process that necessitates
precise monitoring and extensive data analysis at each stage. Furthermore, the DDD …

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically …

Abstract Background Circular RNAs (circRNAs) play important roles in the occurrence and
development of cancer and chemoresistance. DNA damage repair contributes to the …

Triple-negative breast cancer (TNBC) is a relatively aggressive breast cancer subtype due to
tumor relapse, drug resistance, and multi-organ metastatic properties. Identifying reliable …

In many cases of traumatic brain injury (TBI), conspicuous abnormalities, such as scalp
wounds and intracranial hemorrhages, abate over time. However, many unnoticeable …

Pilocytic astrocytoma (PA), the most common pediatric brain tumor, is driven by aberrant
mitogen-activated protein kinase signaling most commonly caused by BRAF gene fusions or …

Triple–negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer
with a poor response rate to conventional systemic treatment and high relapse rates …

Matching patients to optimal treatment is challenging, in part due to the limited availability of
real-world clinical datasets for predictive biomarker identification. The growing integration of …

Although metabolic reprogramming within tumor cells and tumor microenvironment (TME) is
well described in breast cancer, little is known about how the interplay of immune state and …